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Trepanier LA
Cytochrome P450 and its role in veterinary drug interactions.

Vet Clin North Am Small Anim Pract, 36(5): 975-985, 2006
ISSN: 0195-5616 The Veterinary Clinics of North America - Small Animal Practice (PubMed)

Abstract
Cytochrome P450 (CYP) enzymes are common sites of drug interactions in human beings. Drugs may act as inhibitors or inducers of CYPs, leading to altered clearance of a second drug. Clinically relevant drug interactions involving various CYP isoforms in people, including CYP1A2, CYP2C9, CYP2D6, and CYP3A4, have been well documented. Analogous interactions are beginning to be characterized in dogs, for which canine CYPs share many of the same substrate ranges as in human beings.

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