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Noli C, Koeman JP & Willemse T
A retrospective evaluation of adverse reactions to trimethoprim-sulphonamide combinations in dogs and cats.

Vet Q, 17(4): 123-128, 1995
ISSN: 0165-2176 The Veterinary Quarterly (PubMed)

Abstract
Adverse reactions to various trimethoprim-sulphonamide (T-S) combinations were studied retrospectively in dogs amd cats referred to the Utrecht University Department of Clinical Sciences of Companion Animals during the period 1985-1994. Dermatological and systemic reactions were observed im 19 dogs and 2 cats. Specific histological reaction patterns were seen in 3 dogs with toxic epidermal necrolysis, in 1 dog and 1 cat with erythema multiforme, and in 1 dog with pemphigus foliaceus. Diagnostic criteria used in humans proved to be reliable in dogs and cats as well. Adverse reactions were observed within 7-14 days after administration and were most often due to sulphadiazine (76%) and sulphatroxazole (14%). The incidence of adverse reactions to T-S was 0.25%.

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